Description

INSTANT DOWNLOAD COMPLETE TEST BANK WITH ANSWERS

 

 

The Biology of Cancer 2nd Edition By Robert A. – Test Bank

 

 

Sample  Questions

 

 

The Biology of Cancer, 2nd Edition, Question Bank

© 2014 Garland Science

Chapter 3 Tumor Viruses

Level 1: Comprehension of reading, knowledge of terminology

Level 2: Understanding and application of information to compare and contrast or interpretation of data

Level 3: Analysis and application of information to a problem, an experiment, a secondary concept, or previous knowledge

  • Dulbecco and Rubin discovered that they could infect chicken embryo fibroblasts with RSV in culture. Which of the following was NOT a characteristic exhibited by these cells after they were infected? (Level 2)
  1. Virus particles were produced by these cells for many weeks.
  2. Cells formed clusters, or foci, after infection.
  3. The cells seemed to demonstrate uninhibited proliferation.
  4. The cells exhibited flattened morphology.
  5. The cells exhibited metabolic properties similar to those observed in tumor cells.

 

  • Experiments using temperature-sensitive mutants of RSV to infect chicken embryo fibroblasts demonstrated that (Level 2)
  1. Infection with RSV is necessary to initiate transformation of these cells, but the RSV genome is not needed to maintain the transformed state.
  2. The RSV transforming gene is necessary for both the initiation and maintenance of transformation in these cells.
  3. Infection with RSV alone is unable to transform these cells.
  4. Cells infected with RSV continue to exhibit normal cellular morphology.
  5. None of the above.

 

  • Which of the following is considered to be a tumor virus? (Level 1)
  1. Hepatitis B virus (HBV)
  2. Human papillomavirus (HPV)
  3. Shope fibroma virus
  4. Human adenovirus 5
  5. All of the above

 

  • Which of the following is a property of transformed cells? (Level 2)
  1. Rounded shape
  2. Reduced requirement for mitogenic growth factors
  3. Loss of contact inhibition
  4. Increased transport of glucose
  5. All of the above

 

  • The ability of cells suspended in soft (semi-solid) agar medium to form colonies is a good predictor that (Level 3)
  1. These cells will form tumors if injected subcutaneously into immunocompromised mice.
  2. These cells have stopped proliferating and will die.
  3. These cells would fail to grow in normal medium.
  4. These cells have an increased requirement for growth factors.
  5. None of the above.

 

  • Once a cell has been infected with a virus, how might viral genes be transmitted from mother to daughter cells? (Level 2)
  1. Viral DNA carries its own replication machinery, replicating its own genome independently of host enzymes.
  2. Viral DNA may be integrated into the host cell’s chromosomes, so that it is replicated along with host DNA prior to cell division.
  3. Viral DNA may be linked to host DNA through protein bridges, allowing it to tag along with host chromosomal DNA during cell division.
  4. B and C.
  5. All of the above.

 

  • Which of the following enzymes are encoded by retroviral DNA? (Level 2)
  1. Reverse transcriptase.
  2. RNA polymerase II.
  3. A and B.
  4. None of these enzymes are encoded by retroviral DNA.

 

  • A gene found in a normal cell’s genome that can be picked up and altered by a virus to drive cellular transformation is known as (Level 1)
  1. An oncogene
  2. A proto-oncogene
  3. A transgene
  4. A protogene
  5. None of the above

 

  • Scientists may map the insertion sites of viruses in DNA isolated from tumors that formed following retroviral infection in order to (Level 3)
  1. Identify the viral genes responsible for transformation.
  2. Discover new proto-oncogenes.
  3. Determine how viruses suppress tumorigenesis.
  4. Understand how viruses infect cells.
  5. All of the above.

 

  • Some retroviruses are able to transform cells through (Level 2)
  1. Inserting themselves near a proto-oncogene in the host genome.
  2. Acquiring oncogenes within their own genome.
  3. Possessing genes that specify proteins that activate cellular genes involved in proliferation.
  4. A, B, and C.
  5. None of the above.

 

  • Which of the following is true of retroviruses? (Level 2)
  1. They are DNA viruses.
  2. Their replication cycle requires DNA to be transcribed to RNA.
  3. The DNA versions of their viral genomes are called proviruses.
  4. B and C.
  5. None of the above.

 

  • Which of the following is true of c-src? (Level 2)
  1. It is present only in vertebrate cells containing integrated viral DNA.
  2. It results in cellular transformation.
  3. It is an example of a proto-oncogene.
  4. It is highly conserved among vertebrate species.
  5. C and D.

 

  • The Biology of Cancer, 2nd Edition, Question Bank© 2014 Garland ScienceChapter 7 Tumor Suppressor GenesLevel 1: Comprehension of reading, knowledge of terminology

    Level 2: Understanding and application of information to compare and contrast or interpretation of data

    Level 3: Analysis and application of information to a problem, an experiment, a secondary concept, or previous knowledge

    • When a normal cell and a cancer cell were fused, the resulting hybrids lost the ability to form tumors in mice. This suggests that (Level 3)
    1. The cancer cell alleles are dominant over the normal cell alleles.
    2. The cancer cell alleles are recessive to the normal cell alleles.
    3. The normal and cancer cell alleles are co-dominant.
    4. The original tumor formed as a result of infection by a tumor virus.
    5. None of the above.

     

    • Sporadic cases of retinoblastoma require (Level 3)
      1. One inactivating somatic mutation in one copy of Rb.
      2. Two somatic inactivating mutations, one in each of the two copies of Rb.
      3. One somatic mutation in Rb, leading to its activation.
      4. Two somatic mutations in a copy of Rb, leading to its activation.
      5. None of the above.

     

    • Loss of heterozygosity (LOH) at a given locus may occur as the result of (Level 2)
    1. Mitotic recombination.
    2. Gene conversion.
    3. Loss of a chromosomal region.
    4. All of the above.

     

    • Single nucleotide polymorphism markers (SNPs) are found approximately how far apart across the genome? (Level 1)
    1. Every 1 megabase
    2. Every 10 megabases
    3. Every 1 kilobase
    4. Every 10 kilobases
    5. None of the above

     

    • Which of the following is TRUE of methylation in cancer cells? (Level 2)
    1. Overall levels of methylation throughout the cancer cell genome often increase.
    2. There is an increase in DNA methyltransferase enzyme activity.
    3. Areas of CpG islands are hypomethylated.
    4. Areas of CpG islands become methylated inappropriately.
    5. None of the above.

     

    • The APC protein (Level 2)
    1. Is essential for degrading β-catenin.
    2. Causes increased activation of β-catenin.
    3. Helps to regulate cell motility.
    4. A and C.
    5. None of the above.

     

    • Which of the following statements about NF1 is FALSE? (Level 2)
    1. It regulates Ras signaling through positive feedback control mechanisms.
    2. Cells lacking NF1 have higher levels of GTP-bound Ras.
    3. NF1 is known as a Ras-GAP.
    4. B and C.
    5. None of the above.

     

    • You are studying a cell line in which the loss of just one copy of a tumor suppressor gene provides a growth advantage for the cells. This would be an example of genetic (Level 1)
    1. Unilateral mutation.
    2. None of the above.

     

    • HIF-1α levels may go up when (Level 3)
    1. Oxygen conditions are at normal physiologic levels.
    2. Cells are experiencing hypoxic conditions.
    3. Oxygen levels are high.
    4. HIF-1α is bound to pVHL.
    5. C and D.

     

    • Which of the following genes is NOT classified as a tumor suppressor? (Level 2)
    1. MGMT
    2. p16INK4A
    3. PTEN
    4. VHL
    5. None of the above

     

    • Inactivation of tumor suppressor genes can occur as the result of (Level 2)
    1. Somatic mutation.
    2. Promoter demethylation.
    3. Loss of heterozygosity.
    4. A and C.
    5. None of the above.

     

    • You are studying cancer cells, and hypothesize that you have found a previously unidentified tumor suppressor gene. Which of the following results would support your hypothesis? (Level 3)
    1. You have found loss of heterozygosity in the locus containing your gene in a number of human lung cancer samples.
    2. You have identified a gain-of-function mutation in this gene that results in the transformation of normal cells.
    3. Functional analysis has revealed that the wild-type form of the gene that you have identified serves to drive proliferation.
    4. B and C.
    5. None of the above.